Do the smallpox vaccines work to prevent monkeypox?

“Mitjà and co-authors noted that 32
individuals in their cohort (18%) acquired monkeypox infection despite a
smallpox vaccination history, which “warrants further investigation to
better understand the protection provided by vaccination
in the context of the current outbreak.”‘

Smallpox
vaccination of infants ended over 50 years ago. Smallpox was declared
eradicated 45 years ago. So few people in a cohort whose average age is
37 would be expected to have been vaccinated—and the vaccine they
received would have preceded both ACAM-2000 and Jynneos, and been
reliable at preventing smallpox. But it apparently did not prevent
recent monkeypox.

In 2002 it was suggested that vaccination-induced immunity to smallpox was long-lasting. https://www.cidrap.umn.edu/news-perspective/2002/08/smallpox-vaccines-effect-may-last-35-years-researchers-say

We can thank Tony Fauci’s NIAID for sponsoring the original trial (2003)
in which 20 plus year old (expired) smallpox vaccine was diluted to see
how much you really needed. You didn’t need that much. This study
presumably provided the underpinning for the dilution decision regarding
Jynneos.

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