Here is a very good start at diagnosing inherent problems in the medical research enterprise, and suggestions for correcting them.–Meryl BMJ 2017; 357 doi: https://doi.org/10.1136/bmj.j2973 (Published 20 June 2017) Carl Heneghan, director1, Kamal R Mahtani, deputy director1, Ben Goldacre, director EBM DataLab1, Fiona Godlee, editor in chief2, Helen Macdonald, head of education2, Duncan Jarvies, multimedia editor2 A response to…