Can the Vaccine Wars Get Any Weirder? Father of (Unvaccinated) Boy With Leukemia Asks California School Officials to Bar Unvaccinated Students/ NY Times

The son has been treated for leukemia and is still immune-compromised, has not received the live measles vaccine, as it might be dangerous for him. So the dad wants his child protected by forcing everyone else in the school to be vaccinated, to create a safe cocoon (at least while in school) for his child….

WHO mulls reforms to repair reputation after bungling Ebola; must guard against donor fatigue/ AP, BBC, Businessweek

From the AP: GENEVA — The World Health Organization is debating how to reform itself after botching the response to the Ebola outbreak, a sluggish performance that experts say cost thousands of lives. On Sunday, WHO’s executive board planned to discuss proposals that could radically transform the United Nations health agency in response to sharp…

Why do so few European countries recommend flu shots for children?/ Eurosurveillance.org

The data below come from:  Eurosurveillance, Volume 19, Issue 16, 24 April 2014 Few European countries recommend flu shots for children, and  only 3 suggest them for all children above 6 months old, as does the US. Most countries recommend them only for elders, the group most likely to die from flu.  However, elders are…

FDA finds that baboons given DPT shot became carriers (spreaders) of whooping cough/ NY Times

Pertussis (whooping cough) epidemics continue to increase in the US, with 50,000 recorded cases this year. Most people who got pertussis have been fully vaccinated.  Thanks to investigative journalist Sharyl Atkisson for pointing out the baboon research, discussed in the NY Times and published in the Proceedings of the National Academy of Sciences last year.  FDA’s Office of Vaccines…

CDC sends live (not inactivated) Ebola to scientists…just like they did with anthrax and many other deadly bugs / NY Times

Dr. Thomas R. Frieden, director of the Centers for Disease Control and Prevention, is investigating a laboratory mistake that has potentially exposed workers to the Ebola virus. From the NYT:  A laboratory mistake at the Centers for Disease Control and Prevention may have exposed a technician to the deadly Ebola virus, federal officials said on…

Prosecute Torturers and Their Bosses / NY Times Editorial

Email Share Tweet Save More Dick Cheney. CreditWin McNamee/Getty Images From the Sunday NY Times of December 21: Since the day President Obama took office, he has failed to bring to justice anyone responsible for the torture of terrorism suspects — an official government program conceived and carried out in the years after the attacks of…

Swine flu vaccine-induced narcolepsy is costing European governments over $1 Billion due to liability waivers for manufacturers. The same waivers were just issued for Ebola vaccines

The UK is paying out about $1.7 million dollars per victim.  Although the media rarely reported on the severity of narcolepsy cases, vaccine-induced narcolepsy patients are much sicker than most people with narcolepsy.  It isn’t only a matter of falling asleep; there is additional brain damage, including personality changes. Now scientists in Finland, where the…

Media comment on today’s GAO assessment of the FBI’s flawed anthrax science

I chose the following short AP report from the WaPo because it gets right to the point: NATIONWIDE (AP) – The Government Accountability Office says the science the Federal Bureau of Investigations used to investigate the 2001 anthrax attacks was flawed. The GAO released a report Friday on its findings. The agency didn’t take a position on the FBI’s…

GAO Report echoes NAS report that FBI’ s study of anthrax letters leaves much to be desired, including lack of validation of the methods used/GAO

Here is the GAO report released today, two years in the making, a study done for unnamed “congressional requesters.” In past years, the requesters have been listed, but in this case, they are not. This most likely reflects the sensitivity of this matter. Why so sensitive? Because the FBI botched its investigation, never had even…

Forget whether it matches, just get your vaccine! / CDC

CDC has created a litany of excuses for why it recommends flu vaccines for kids despite poor protection against the majority of this year’s influenza strains (H1N1 and H3N2). See below for the data on the poor vaccine match this year. Below are the reasons CDC says parents should still give the current vaccine to their children….

NYC forcing youngest residents to receive poorly effective flu vaccines–or goodbye daycare!

NYC’s unelected health department demanded last December that children aged 6 months to 5 years receive yearly flu vaccinations. This was one of outgoing mayor (and newly minted health expert) Michael Bloomberg’s gifts to the city, along with the banning of extra large soft drinks. Are soft drinks a threat to others?  What right has any…

In vitro, 53 existing *licensed* drugs have activity against Ebola virus entry into cells/ Emerging Microbes and Infections, a Nature publication

Yesterday, authors from the NIH, NY and Toronto published a paper describing their screening system for compounds against Ebola.  The method has identified a large number of approved substances with potential benefits. Many of them have been mentioned in this blog previously, such as clomifene, antimalarials and antiarrhythmics.  Ninety-five additional compounds were also found to…

After Ebola survival, perhaps 40% go on to develop chronic illnesses/ Al Jazeera

I wrote about the fact there was a “post-Ebola syndrome” here, which might include visual problems (usually due to uveitis), joint pains, and psychological issues.  It was not well defined due to the small size of previous epidemics and small number of survivors. Now Al Jazeera has written about several people whose post-Ebola survival is complicated…

Ebola in Africa: Describing and Managing the Disease/ NEJM-MSF

The NEJM published a piece written primarily by Medicins Sans Frontieres clinicians who have worked in Liberia, describing the clinical course of Ebola patients, and concluding with the paragraph below, acknowledging the need to provide more comprehensive care than MSF was able to provide earlier in the outbreak. I believe we are now arriving at a…

Excellent theoretical approach to treating Ebola, from 3 Hong Kong scientists/ BioMedCentral

Just out as a provisional pdf (final version is in production), 3 scientists have reviewed the totality of the published data on Ebola therapeutics, and come up with a framework for combining the use of drugs for their potential synergistic effects.  For me, this put many disparate facts about Ebola into focus, providing much of…

Transparency International Issues Corruption Index Before UN and World Bank meetings on Corruption/ HuffPo

The following story describes this year’s publication of the famed Corruption Perception Index by Transparency International. This annual country metric gets widely discussed. The new index shows that most governments (2/3) “show very high levels of corruption.”  Corruption is criminal, it keeps the criminals in power, it leaves little room for meaningful change and advancement…

Common Sense Approaches to Improving Ebola Survival/ The Lancet

I have been talking about how one might improve clinical care of Ebola patients, and the need for trials to identify the best treatments, best empiric iv fluids, etc.  This is necessary both to improve survival rates and also to give Ebola patients a reason to come to Ebola treatment centers, which many perceive to be…

Movin’ On Up: Now the US will have 53 Ebola-ready hospital beds/ WaPo

I guess 53 beds (located in 35 hospitals) is progress, but not a lot of progress… when you consider that in Africa there have been more than 53 cases from a single town. From the WaPo: … The 35 designated hospitals will have total treatment capacity of 53 beds.In trying to establish a network of…

When Health Care is not a Public Good, why would hospitals agree to take Ebola patients?/ WaPo

The WaPo explores which hospitals will be approved by CDC to treat Ebola patients, and whether hospitals will lose or gain from such a designation. Treating an Ebola patient scares other patients away, puts staff at risk, and demands extraordinary levels of intensive care that exceed what can be reimbursed by insurers, and sometimes what can…

Ebola Treatment: $1 Million/patient here with 80% survival; $20/patient in Africa with 35% survival: we need to find the sweet spot between them, where doable medical care significantly raises survival

I have been desperately seeking ideas to get us to that sweet spot: where medical providers will know how to manage Ebola in Africa, and their treatments will keep most Ebola victims alive, while not costing a million dollars per patient, or more. I envision patients having access to lab tests, iv fluids, convalescent serum, automatic…

Has CDC stopped testing for H1N1 because the pediatric vaccine isn’t working against H1N1?

The Tampa Bay Times (see below) reported today that two Florida children had died of flu. Which is odd, because if you scroll down to the current CDC charts below you will see a) that the mortality from flu and pneumonia is about as low as it gets, right now, and b) only one flu-associated child…

Americans’ Ratings of CDC Down After Ebola Crisis: Gallup

From Gallup:  Americans’ Ratings of CDC Down After Ebola Crisis No other agencies measured showed a decline in ratings PRINCETON, N.J. — Americans’ ratings of the job being done by the Centers for Disease Control (CDC) are down significantly from last year, from 60% saying it is doing an “excellent” or “good” job to 50%….

Experts Tell Congress We Really Need High-Containment Facilities for Ebola (as I’ve been saying)/ NBC

From NBC News: … Although the CDC initially said any U.S. hospital should be able to care for an Ebola patient, Gold (Chancellor of the University of Nebraska Medical School, where 3 victims were treated) argued that it really often does require a special biocontainment unit. There are only four in the country: at Nebraska,…

A Sticky Issue: Quarantining Semen (or sweat) in India after Ebola Recovery/ TIME

US media have been silent about this elephant in the room: those who recover from Ebola are likely to have positive PCR tests of semen, vaginal fluid, breast milk, urine and skin (including sweat) for one to several months after recovery.  There are several anecdotes describing disease transmission to a partner following recovery. Because it…

Military and Nebraska Medical Experts Weigh In on Containment Needed for Ebola/ Annals of Internal Medicine online

Click here for the full, free text.  Ideas and Opinions | online 16 October 2014 Caring for Patients with Ebola: A challenge in Any Care Facility Mark G. Kortepeter, MD, MPH; Philip W. Smith, MD; Angela Hewlett, MD; and Theodore J. Cieslak, MD The largest outbreak of Ebola virus continues unabated in West Africa. With the recent death of a…

Better approach to conducting Ebola treatment trials in Africa

Admittedly, I am biased about how I think clinical trials should be conducted.  I believe they necessitate the very finest care of patients, meticulous ethical conduct, and collection of the most complete data possible.  Most importantly, data obtained from human subjects, who have taken on some risk to advance medical knowledge, should imho never be…

IOM workshop admits they don’t know what we said they don’t know

Ten months into the out-of-control Ebola epidemic, and 38 years since the first Ebola epidemic, the DHHS Assistant Secretary of Health for Preparedness, Nicole Lurie, had a workshop convened by IOM with NIH, CDC, NIOSH, academics, etc. to discuss what needs to be learned about Ebola, and how research can address these questions. Here is…

Ebola Clinical Illness in Well-Described Patients: The US healthcare system can only successfully handle a little Ebola

Let me start this piece with the bottom line: I want to be clear that patients with Ebola virus disease are sicker, in general, than patients with any other medical condition, in the US or anywhere else. They are subject to many more serious complications than other patients. They require more care, more lab tests, more procedures,…

Can the American people now learn what it takes to keep someone with Ebola alive?

According to the Washington Post, NY’s Bellevue Hospital plans to discharge Dr. Craig Spencer tomorrow. This is great news.  Everyone who has been treated in the US, with the exception of Eric Duncan, has survived Ebola.  All those we know about (9 people) were diagnosed and treated early, except Mr. Duncan. This is an 89%…

Useful Ebola Info from a 2009 report on emerging infectious diseases and their effect on the blood supply

Here’s the Report, written by the Transfusion Transmitted Disease Committee of the American Association of Blood Banks. Notable quotes: Physicochemical properties: Stable at room temperature and can resist desiccation (drying); inactivated at 60°C [140 F] for 30 minutes [However, the 1984 Mitchell and McCormick paper that studied virus inactivation found that the time to inactivation…

More monoclonal or polyclonal antibodies recommended for treating Ebola/ Reuters

This type of approach is what I recommended in my Congressional testimony in 2001, for many potential pathogens, following the anthrax letters. What are monoclonal antibodies? The human immune system takes apart microbial pathogens and manufactures antibodies to a variety of sites on the microbe, honing its response as the infection progresses. Nearly 40 years…

“The nasal spray version of the flu vaccine did not protect young children against swine flu last year and might not this year”/AP

From the Associated Press: The nasal spray version of the flu vaccine did not protect young children against swine flu last winter and might not work again this year, health officials said Thursday. Preliminary results from three studies found that AstraZeneca’s FluMist had little or no effect in children against swine flu. That was the…

What About Testing Already-Licensed Drugs Against Ebola? Here are some that may be promising

I will elaborate on this important subject as I learn more.  And what more has been learned about the benefits of lamivudine, an antiviral used by a Liberian doctor with reported high survival in a small number of patients?  UPDATE Nov 14:  A WHO committee says it does not work.  MSF will test 2 antiviral…

FDA has issued Emergency Use Authorizations for Ebola diagnostic tests, but not for vaccines or drugs/ FDA

The following table is current as of October 27, 2014 per FDA.  Experimental drugs are being authorized on a compassionate use basis, for those already ill from Ebola.  I find no legal authority in the US for using experimental vaccines currently. Diagnostic Test Date Letter ofAuthorization (PDF) Fact Sheet for Healthcare Providers (PDF) Fact Sheet for Patients…

To develop and test new drugs and vaccines, you need the latest strains of Ebola–but researchers have been blocked from getting them. Why? / Reuters

Whatever happened to that Ebola czar?  He could, if he wanted, cut through any red tape blocking the sharing of new Ebola samples (which in some cases do not even have to be live, and therefore shipping issues should disappear) in a few minutes.   I doubt this is a red tape issue.  Blocking even…

India will stockpile and distribute grains to the poor, despite WTO/Reuters

In the news today is the story of how India has refused to agree with a World Trade Organization (WTO) demand that it scale back its stockpiling of grains.  I recall when the IMF/World Bank demanded something similar of African governments decades ago.  The governments sold off their stockpiles in exchange for IMF loans. Soon…

“U.S. scientists say uncertainties loom about Ebola’s transmission, other key facts”/ Reuters

Reuters’ Sharon Begley has to be one of the very best science journalists in the US.  She always gets to the meat of the matter.  Here she gives us the highlights of what scientists said remains unknown about Ebola transmission, at an IOM meeting November 3.  The full article is below, and it confirms what…

“The AP and other press outlets have agreed not to report on suspected Ebola cases until a positive viral RNA test is completed”/ Forbes

And that could be why we are hearing so little despite multiple suspected cases around the country. Sunday, Nov. 2, someone recently returned from Liberia developed a fever, and was hospitalized at Duke.  The publicy learned about this because a doctor at Duke is also a Forbes journalist, who had not signed on to the…

CDC now admits there IS a (low) risk of infection, if you are on a plane or in a room with a symptomatic Ebola patient/ CDC

CDC changed its story again.  As of October 27, CDC updated its risk guidelines to acknowledge that being in a room or on a plane with someone who is symptomatic with Ebola puts others at low, but not zero, risk of contagion.  I applaud CDC for this change.  It admits there is much we do…

NY Times Explains the PPE Evolution

I would recommend that healthcare workers read the complete article.  We are used to outfit #1, but the details for #2 and #3 (especially their removal) are hazy for many of us, since we have never before had to use this level of personal protection to protect ourselves from our patients’ infections. http://www.nytimes.com/interactive/2014/10/15/us/changes-to-ebola-protection-worn-by-us-hospital-workers.html Changes to…

Ebola: worldwide dissemination risk and response priorities/ The Lancet

This piece in the Lancet, authored by Cowling and Yu, discusses issues of Ebola dissemination and means to reduce spread to other countries.  Its final paragraph discusses what we do not yet know, but need to learn: There are several important near-future research needs. Perhaps most urgent is a better understanding of the effectiveness of…

Why is Ebola droplet spread controversial, when CDC, NIH and WHO have long acknowledged it?

From CDC regarding how one must handle laboratory specimens from someone with Ebola: “Clinical specimens [such as blood or urine] from persons suspected of being infected with one of the agents listed in this summary (Ebola is listed as BSL-4 on page 251) should be submitted to a laboratory with a BSL-4 maximum containment facility.”…

We Are Ignoring the US’ $440 Million Surge Capacity for Ebola vaccine production

Ebola is killing 60-70% of those affected, even with treatment.  Manufacturers say it will take quite a while to produce sufficient supplies of a vaccine, and that bulk manufacturing will only begin after one of several vaccine candidates is chosen. This makes no sense. The US government spent $440 million to help 3 companies develop…

Hospitals are not ready, and cannot become ready: Ebola requires new healthcare facilities. Ebola is a huge money-loser; will hospitals take these patients?/ AP

On Sept 30 I wrote a blog post about how CDC’s Director Frieden was wrong to claim that any US hospital could manage an Ebola patient.  Circumstances sadly proved me right in the case of Dallas, Texas.  Has that changed now that we have had more time to prepare? After the death of Thomas Eric…

Emerging targets and novel approaches to Ebola virus prophylaxis and treatment.

This article discusses literally a couple dozen vaccines and drugs that are in development for Ebola.  How is their testing being fast-tracked ? BioDrugs. 2013 Dec;27(6):565-83. doi: 10.1007/s40259-013-0046-1. Choi JH1, Croyle MA. Author information Abstract Ebola is a highly virulent pathogen causing severe hemorrhagic fever with a high case fatality rate in humans and non-human primates (NHPs)….

The survival of filoviruses (Ebola and Marburg) in liquids, on solid substrates and in a dynamic aerosol (Thx Washington’s Blog)

J Appl Microbiol. 2010 Nov;109(5):1531-9. The survival of filoviruses (Ebola and Marburg) in liquids, on solid substrates and in a dynamic aerosol Piercy TJ1, Smither SJ, Steward JA, Eastaugh L, Lever MS. Author information Abstract AIMS: Filoviruses are associated with high morbidity and lethality rates in humans, are capable of human-to-human transmission, via infected material such as blood, and are…

CDC now admits Ebola can float through the air, and land on doorknobs/ CDC

CDC issued a new poster Friday night October 24, which admits Ebola may in fact be airborne. But CDC says it doesn’t travel farther than 3 feet.  Well, at least CDC is starting to move the narrative.  Maybe tomorrow it will be 5 feet.  Then 10.  Maybe next month they will tell us why all…

5 Ebola patients in Kikwit outbreak had no physical contact to explain transmission, and scientists suggest other mechanisms

The following paper was written by CDC scientists in 1999. J Infect Dis. 1999 Feb;179 Suppl 1:S92-7.  Ebola Hemorrhagic Fever, Kikwit, Democratic Republic of the Congo, 1995: risk factors for patients without a reported exposure.  Roels TH1, Bloom AS, Buffington J, Muhungu GL, Mac Kenzie WR, Khan AS, Ndambi R, Noah DL, Rolka HR, Peters CJ, Ksiazek TG. Author information Abstract In 1995, 316 people became…

NY/NJ/IL impose health care worker quarantine after NYC doctor and unidentified heallthcare worker at Newark Airport hospitalized for potential Ebola/ WaPo

A quarantine will help stop cases appearing in the US in the near-term, but may mean that fewer medical professionals will volunteer to work in Africa, making control of Africa’s epidemic harder, thus making things worse for the US in the long-term.  (Only 0.5% of MSF staff or less have developed Ebola.) From today’s WaPO:…

Look, CDC is simply lying. Its own publications acknowledge that Ebola may aerosolize, and must be contained in BSL-4 facilities (that are not currently available in any ordinary hospitals) / CDC

Ebola is a designated BSL-4 (Biosafety Level 4) virus.  It requires the maximal level of containment possible.  [Anthrax, by the way, is less dangerous, requiring less containment (BSL-3) than Ebola.]  Ebola’s mortality rate is the highest I know of, for any infectious disease. CDC acknowledges (below, in a 2009 publication on page 45) that Ebola requires…

Ebola Causes Chronic Illnesses in Those Who Manage to Recover/ CBS and USAMRIID

From CBS: But unfortunately, Ebola survivors do often develop certain chronic inflammatory conditions that affect the joints and eyes, problems that can follow a survivor through the remainder of their life. Dr. Amar Safdar, associate professor of infectious diseases and immunology at NYU Langone Medical Center, told CBS News these chronic conditions are a result…

Indemnifying Pharma for Ebola Vaccines: Recipe for Problems?

When did pharmaceutical manufacturers demand to be indemnified by governments, when previously asked to produce vaccines? First time:  1976 swine flu.  One soldier died of swine flu at Fort Dix, the virus never did spread through the US population, but 45 million Americans were vaccinated with an unecessary vaccine, several hundred developed Guillain Barre syndrome…

Airborne Spread of Ebola from Pigs to Macaques/ Nature

Not sure why this is still a subject for debate.  Animal models establish that Ebola can be transmitted via aerosol secretions under lab conditions.  The question remaining is how often this happens in humans. Maybe it does; maybe it doesn’t. Despite CDC protestations regarding airborne spread, the new guidelines for personal protective equipment issued by…

MSF discusses treatment approaches and its role in therapeutic drug trials

Below are excerpts from a longer discussion here.  As one of the main providers of Ebola treatment in West Africa, MSF has chosen to take an active role in trialling experimental treatments. We add value to the trial process as we have access to large numbers of patients and therefore potential recipients of the experimental…

Excellent review of experimental vaccine and drug approaches to Ebola/ 2nd Canadian drug review

I read the full text but can’t post it due to copyright.  The first review is from U Texas.  BioDrugs. 2013 Dec;27(6):565-83. doi: 10.1007/s40259-013-0046-1. Emerging Targets and Novel Approaches to Ebola Virus Prophylaxis and Treatment Choi JH1, Croyle MA. Abstract Ebola is a highly virulent pathogen causing severe hemorrhagic fever with a high case fatality rate in humans…

CDC defined infectious respiratory droplet transmission as different than airborne

Here are CDC’s definitions for the different modes of spread of infectious agents.  Scroll down to IB3b and c and you will see that CDC has defined droplet transmission as a form of contact transmission. This may be CDC’s technical justification for insisting that Ebola does not spread via the airborne route, when there is ample evidence…

Extreme Abundance of Caution Versus Extreme Abundance of Hubris in Ebola Scare

From NBC news today:   A helicopter landed aboard a cruise ship Saturday to pick up a blood sample from a passenger who may have handled fluids from an Ebola patient, ahead of the Carnival Magic’s planned docking at Galveston, Texas, Sunday. Carnival said Texas health officials requested that a sample be taken from the…

Aerosolization tests of Ebola in Animals at USAMRIID confirms disease can spread via air

Because there is so much confusion about the issue of airborne spread of Ebola, this article should clarify the fact that our premier biodefense lab clearly shows that transmission through air may cause infection.  The article is titled, “Development of a Murine (mouse) Model for Aerosolized Ebolavirus Infection Using a Panel of Recombinant Inbred Mice.”…

Expanded Oct. 19: Current Clinical Thoughts on Ebola

My thoughts on handling Ebola, which garnered so much interest that I have expanded the original ideas, including updates and links: 1. Personal Protective Equipment Even the best containment gear, combined with a diluted bleach solution to spray down workers as layers are removed, and a buddy system that requires another healthcare professional to watch…

Drilling Down Into the Facts Regarding Airborne Spread of Ebola/ CIDRAP (U MInnesota)

I will post this article in its entirety, but will put the most interesting bits in red so readers can skim the piece for these if they wish–Meryl COMMENTARY: Health workers need optimal respiratory protection for Ebola cidrap.umn.edu /news-perspective/2014/09/commentary-health-workers-need-optimal-respiratory- protection-ebola Lisa M Brosseau, ScD, and Rachael Jones, PhD | Sep 17, 2014 Editor’s Note: Today’s…

Ebola Opinion: What do you do when you can’t tell those with Ebola from patients with other conditions?

Distinguishing Ebola cases from others is the most immediate need for health care providers and patients.  If you cannot determine immediately who is infected, patients with other conditions will be lumped with possible Ebola patients, and may contract Ebola as a result of healthcare! Even worse (from the point of view of medical providers) is…

New Evidence that Artificial Sweeteners are Poisons/ WaPo

If you were ever my patient and asked about artificial sweeteners, you would have gotten an earful. There is so much available data on the problems with them.   And the study referenced here suggests artificial sweeteners actually cause the problem that are supposed to be helping to prevent or ameliorate:  glucose intolerance. From today’s…

Cuba Responds To Ebola Crisis As Black Market For Convalescent Serum Emerges/ Forbes

Where can you find hundreds of doctors who can leave their practices and deploy to Africa?  In Cuba, where they have deployed large numbers of doctors to Africa many times before.   Cuba has a higher doctor-patient ratio than the US. Cuba uses American medical textbooks to train its doctors and has a very high…

Ebola strategies/ Nass

I anticipate a huge loss of life from Ebola in Africa, due to the lack of medical and all other infrastructure in so much of the continent. Africans are like everyone else:  they want to save their family members.  If treatment centers are available that will increase the chance of survival, they will utilize them….

Over 1,100 “Incidents” (aka escapes) with dangerous “Select Agents” were reported in the US during 2008-2012/ USA Today

Just in case you thought that CDC and federal regulators had things under control regarding research on microorganisms that can be used in bioterrorism, think again.  There were an average of 4 reported escapes each week over the 5 years that ended with 2012. From USA Today, “The only thing unusual about the CDC’s recent…

Legal Ramifications of Declaring a Public Health Emergency

I noticed that 2 old posts of mine about the laws and regulations governing public health emergencies were getting a lot of attention this week.  I thought I would post them again, as they may soon be relevant here, and are already relevant to Africans faced with quarantines, cordon sanitaires and other legal and physical…

Ebola therapeutics from China, Canada, Germany, US: promising but without human testing for Ebola, though the last article suggests already-licensed drugs may be useful

Virus Res. 2014 Jun 12;189C:254-261. doi: 10.1016/j.virusres.2014.06.001.  A highly immunogenic fragment derived from Zaire Ebola virus glycoprotein elicits effective neutralizing antibody.  Wang Y1, Liu Z1, Dai Q2. In order to produce polyvalent vaccines based on single rVSV vector, we investigated the immunogenicity, antibody neutralizing activity, and antigenic determinant domain of Zaire Ebola‘s fragment MFL (aa 393-556) that contains furin…

Ebola Opinion / Nass

Despite an estimated 69% death rate, Medicins Sans Frontiers (Doctors Without Borders or MSF) doctors and nurses have not come down with the disease.  MSF has 676 staffers working on the ground in Africa.  CDC has 31 to help with case-finding, but none treating victims.  WHO says it has 141 people in West Africa sent…

Of several potential Ebola vaccines, here is one

Go to: ABSTRACT This 2008 article (available free in full text here) described a very promising Ebola vaccine from USAMRIID: Clin Vaccine Immunol. Mar 2008; 15(3): 460–467. Published online Jan 23, 2008. doi:  10.1128/CVI.00431-07 Vaccine to Confer to Nonhuman Primates Complete Protection Against Multistrain Ebola and Marburg Virus Infection Dana L. Swenson,1 Danher Wang,2 Min Luo,2 Kelly L. Warfield,1 Jan Woraratanadharm,2 David…

Many unlicensed, experimental Ebola treatments and vaccines exist: Dr. Brantly can give informed consent to use them

Since Ebola first was identified in 1976, there have been at least a dozen outbreaks and at least 5 strains have been identified. Serologic tests for Ebola have been available since 1977. The US did not ignore Ebola.  It posed a threat as a natural illness, and posed a different threat as a potential biological…

Inspector General Reports: Biosecurity at Multiple Agencies (including CDC and NIH) a Joke/ USAToday

From USAT: … CDC has not responded to USA TODAY’s requests, under the Freedom of Information Act, filed in June 2012, for records involving lab safety and security incidents at the lab complex. The latest set of “restricted” inspector general audits covered six federal entities conducting research on potential bioterror germs. Additional audits looked at…

What happened to the last safety czar you appointed? Asked who this was, the CDC Director didn’t know/ Reuters

I am posting the entire Reuters story below. Is it funny, pathetic, or both? CDC Director Tom Frieden promised Congress to appoint a senior official to oversee lab security in a 2012 letter responding to a Congressional inquiry. Asked about this person at the House Energy and Commerce Oversight and Investigations Hearing on Wednesday (at…

CDC says there were 269 separate, reported incidents of lost or escaped ‘select agent’ microbes in 2010/ Reuters

Not to put too fine a point on it, but today’s Reuters story has even more bad news on safety at our highest containment labs: According to a 2012 report by CDC scientists, there were 16 incidents of lost or escaped microbes from select-agent labs in 2004, meaning everything from misplaced samples to an infected…

CDC scientists’ lack of understanding of anthrax is shocking and terrifying

The WaPo has published the full text of the CDC report on its anthrax mishap last month, with mention of a number of other, almost identical mishaps…one even from the same lab… in which highly virulent, live bacteria, including anthrax, H5N1 avian flu and Clostridium botulinum were transferred to other labs, on the assumption they were benign…

Nevada Democrats pick ‘None of these candidates’ for governor in Primary/ WaPo

In light of the Eric Cantor defeat in Virginia’s Republican primary, that fact that more Nevada voters cast votes for a “None of the Above” option than for a candidate is interesting.  Voters are fed up in both the east and west.  From the Washington Post blog: “And the winner is — no one. More…

Vodaphone issues report on requests for data by many countries

A WaPo Saturday article, based on a detailed report by the company Vodaphone, details how many other countries do exactly what the US government does with digital data, including the content of phone calls: scoop up everything they want: …In the Czech Republic, for example, the government compelled Vodafone to turn over the content of…

Biowatch–the unworkable system for detecting bioweapons in the air–finally cancelled after wasting over $1 billion

From David Willman at the LA Times: WASHINGTON — Amid concerns about its effectiveness and multibillion-dollar cost, the Department of Homeland Security has canceled plans to install an automated technology that was meant to speed the 24-hour operations of BioWatch, the national system for detecting a biological attack. The cancellation of the “Generation 3” acquisition was made…

A woman giving birth in America now is more likely to die than a woman giving birth in China/WaPo

What is the tag line?  Don’t be poor in America.  Healthcare is simply too expensive for a sizable number of Americans to afford, so they go without.  And this is the result.  True, there are more high-risk pregnancies in the US than there used to be, but that is equally true for other developed countries….

Looking to sales growth, Merck rolls out vaccine adherence plan using electronic medical record

The Electronic Medical Record has a new application: to sell more vaccines. The following article comes verbatim from FierceVaccines, while a link to Forbes tells the same story, although its slant emphasizes improvements in health outcomes, rather than Merck profits. Merck has partnered with a cloud-based electronics medical record company to gain information on patients who…

Nancy Haigwood was central in defining Bruce Ivins as a psychopathic criminal. Why?

How did Professor Haigwood come to make the case against Ivins?  It appears that (like Jean Duley, Ivins’ trainee therapist who was under house arrest when she was brought by FBI to obtain a restraining order against Ivins, then was trotted out for all major media by the FBI before she went into hiding) Haigwood too received…

What are the mechanisms by which corruption operates in the US? Some breathtaking examples of bonuses and revolving doors are discussed by Michael Krieger

Why is the country practically bankrupt and mired in corruption? Can the parts of our economic culture that enable huge government giveaways be identified? We certainly don’t know about how most decisions are made at the federal level, nor do we have any idea how much money changes hands and how.  But there are some…

Syria’s chemical weapons attack(s) an Erdogan False Flag/ Seymour Hersh

Seymour Hersh provides a very plausible deconstruction of how chemical weapons were used in an attempt to draw the United States into military engagement with Syria last year—by the Turkish government in cahoots with anti-Assad Syrian rebels. Hopefully you have heard about the leaked YouTube audiotape in which planning for a Syria false flag attack is…

Anthrax Industry report published/ Research and Markets

Wondering which corporations feed at the anthrax biodefense rice bowl?  For a minimum of $995 (US) you can find out about where the anthrax money is being spent and who’s doing what. Yet the biggest feeder (Emergent BioSolutions) is missing from the list. So is Pharmathene, which was perhaps Emergent’s biggest competitor, and which just…

UN Human Rights Committee Finds US in Violation on 25 Counts/ Truthout

This is a very long piece, but it needs to be said and all the points are important.  The US’ record on Human Rights is pitiful, and our commitment to our international  obligations doubly so.  From Truthout: (Illustration: Lance Page / t r u t h o u t) While President Obama told the country to…

The CIA should cooperate with the Senate on torture report/ WaPo editorial

The Senate committee votes whether to declassify on April 3.  Give the committee members your opinion. Maine’s Senators Collins and King will vote to declassify.  Here is WaPo’s: AT THE heart of the dispute between the Senate Select Committee on Intelligence and the Central Intelligence Agency is a document known as the CIA’s internal review. This is…

Is American democracy headed to extinction? WaPo editorial

Behind dysfunctional government, is democracy itself in decay? It took only 250 years for democracy to disintegrate in ancient Athens. A wholly new form of government was invented there in which the people ruled themselves. That constitution proved marvelously effective. Athens grew in wealth and capacity, saw off the Persian challenge, established itself as the…

5 years after H1N1 Swine Flu was discovered, what do we know about Pandemrix and Narcolepsy?

1.  How widely was Pandemrix vaccine used? Virtually all the narcolepsy data comes from Europe, where the GlaxoSmithKline Pandemrix swine flu vaccine was given to about 31 million Europeans and was used in 47 countries.  It was used in Canada (12 million doses) and a number of developing countries, but little is known about increased cases…

U.S. Scurries to Shore Up Spying on Russia In Crimea: Russia May Have Gotten a Jump on West by Evading U.S. Eavesdropping/ WSJ

Here we go again.   Twenty-five years ago, the US intelligence community did not know that the USSR was about to fall.  Since then, many hundreds of billions of dollars have been spent by the intelligence agencies, but they still missed the boat on the invasion of Crimea–a subject that should have been of utmost…

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